解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A recent study has demonstrated secondary amyloidosis in dogs treated with continuous intravenous insulin infusion. Since elevated levels of serum amyloid A protein (SAA) and diminished amyloid fibril degrading activity (AFDA) are associated with amyloidosis, we measured SAA and AFDA in ten type I diabetics treated wi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.32.1.88
更新日期:1983-01-01 00:00:00
abstract::The interaction of insulin with the vascular endothelium was studied using bovine aortic endothelial cells in monolayer cultures. Confluent cell cultures exhibited specific binding of 125I-insulin to high- and low-affinity cell surface receptor sites. Binding was reversible, saturable, and accompanied by internalizati...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.31.12.1077
更新日期:1982-12-01 00:00:00
abstract::Large glucagon immunoreactive substances, extracted from the fetal bovine pancreas and separated by gel filtration in the presence of 6 M guanidinium-hydrochloride, were submitted to lectin-sepharose affinity column chromatograph. Gel-filtered peak I (approximately 45 K delta) and peak II (approximately 10 K delta) in...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.31.11.1002
更新日期:1982-11-01 00:00:00
abstract::The hyperinsulinemia of obese rodents has been associated with a reduced number of hepatic insulin receptors except in hepatocytes from fatty Zucker rats. We isolated liver plasma membranes from 10-11-wk-old lean and fatty Zucker rats, some of which were injected with streptozotocin 2--4 wk earlier. We have determined...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.10.867
更新日期:1982-10-01 00:00:00
abstract::Susceptibility of mice to experimental insulin-dependent diabetes as induced by multiple subdiabetogenic doses of streptozotocin has been shown to be strongly gender-dependent, males being much more susceptible than females. We examined this gender difference further in two strains of genetically susceptible mice to d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.8.724
更新日期:1982-08-01 00:00:00
abstract::Exciting new findings have been reported in the past few years that indicate that islets can be transplanted successfully across major histocompatibility barriers without the continuous use of immunosuppressive agents by techniques designed to eliminate passenger leukocytes. In vitro culture of donor islets either at ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.31.4.s11
更新日期:1982-08-01 00:00:00
abstract::Filtered proteins including insulin are absorbed in the proximal tubule by means of pinocytosis. The first step in this process is binding of the protein to brush border membrane. As it is not known whether absorption exhibits specificity, we set out to determine whether specific binding sites for insulin are present ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.7.618
更新日期:1982-07-01 00:00:00
abstract::A simple method for the elimination of labile glycohemoglobin in the chromatographic quantitation of glycosylated hemoglobin is described. Use is made of the instability of Schiff base adducts in acidic solution. Erythrocytes are lysed with a pH 5 buffer. At this pH dissociation reaches completion during sample prepar...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.7.630
更新日期:1982-07-01 00:00:00
abstract::Pancreatic islets contain enzyme activity which catalyzes the phosphorylation by MgATP of cardiac, skeletal, or smooth muscle myosin light chains. The enzyme is activated by calcium (Ka = 10 microM) and calmodulin (Ka = 2 nM) and inhibited by trifluoperazine (Ki = 10 microM), a known inhibitor of calmodulin and of ins...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.6.566
更新日期:1982-06-01 00:00:00
abstract::Direct methods for measuring the secretion rate of insulin are too cumbersome for clinical application. Since C-peptide is secreted in an equimolar ratio with insulin and is excreted into the urine, measuring the urinary excretion rate of C-peptide (U-C) could serve as an indicator of its secretion rate (SR-C) if its ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.5.449
更新日期:1982-05-01 00:00:00
abstract::Pancreatogenic diabetes (PD), secondary either to chronic calcific pancreatitis or to pancreatectomy, is characterized by higher frequency of hypoglycemic events during insulin therapy in comparison with type I insulin-dependent diabetes (IDD). Not only glucagon deficiency, but an enhanced peripheral tissue sensitivit...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.4.346
更新日期:1982-04-01 00:00:00
abstract::Heart rate and RR variation (the standard deviation of the mean RR interval for a 5-min period) were evaluated as measurements of cardiac parasympathetic nervous system activity in fasting supine diabetic (N = 22) and comparable age normal (N = 22) subjects. The rate of breathing did not effect heart rate, but was inv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.4.339
更新日期:1982-04-01 00:00:00
abstract::Human fetal pancreatic glands were obtained from 12 consecutive prostaglandin-induced abortions. Explants cultured for 1 day were frozen at 0.3 degree C/min in a 1 M DMSO-containing medium and stored at -196 degrees C. After storage for 3-4 mo the frozen material was rapidly thawed and cultured 1 day before being test...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.3.238
更新日期:1982-03-01 00:00:00
abstract::The exposure of primary cultures of hepatocytes to insulin. 10(-8) M, for 16 h results in a decrease in high affinity insulin binding with no alterations in lower affinity binding. This is reflected in a decrease in the sensitivity, but normal responsiveness, of cultured hepatocytes to the acute effect of insulin on t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.2.145
更新日期:1982-02-01 00:00:00
abstract::Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A,-B,-C, and -DR antigens in 34 Japanese juvenile-onset diabetic patients. The focus of our current work was HLS-DR antigens because there have been few studies of Japanese with this disease. A significant increase in the freque...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.2.105
更新日期:1982-02-01 00:00:00
abstract::This study examined the suitability of commercial U.S.P. insulin as a bacterial growth medium. Purified port insulin (Iletin II, Eli Lilly & Co., Indianapolis, Indiana) was inoculated with approximately 500,000 bacteria per ml of: (1) Staphylococcus epidermidis, (2) Staphylococcus aureus, or (3) Escherichia coli. All ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.1.36
更新日期:1982-01-01 00:00:00
abstract::Rat islets contain the acid-labile activator of phosphofructokinase, fructose-2,6-bisphosphate. The islet content in activator is higher in islets exposed to glucose (16.7 mM) than in islets deprived of glucose. The islets display fructose-6-phosphate, 2-kinase activity with a Km for fructose-6-phosphate close to 0.08...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.1.90
更新日期:1982-01-01 00:00:00
abstract::Nonhuman primates have been used for a variety of studies on diabetes mellitus. Spontaneous, natural forms of diabetes have been well documented in several species; there are limited data on numerous other species that indicate diabetes or a diabetes-like syndrome. The causes and manifestations of spontaneous diabetes...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.31.1.s37
更新日期:1982-01-01 00:00:00
abstract::The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the s...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.12.1045
更新日期:1981-12-01 00:00:00
abstract::The effect of metabolic near-normalization, induced by continuous subcutaneous insulin infusion, on the exaggerated microalbuminuria of exercise was studied in eight insulin-dependent diabetic men selected for normal resting albuminuria. Patients were studied in randomized order during the ordinary glycemic control of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.10.818
更新日期:1981-10-01 00:00:00
abstract::The effects of varying concentrations of ethanol (1, 10, and 30 mM) and its metabolites (1 mM acetate and 1 and 10 mM acetaldehyde) on insulin and glucagon secretion induced by glucose (11.1 mM) and arginine (20 mM) were studied in isolated perfused pancreas of Sprague-Dawley rats. Ethanol and its metabolites did not ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.9.705
更新日期:1981-09-01 00:00:00
abstract::Exposure of isolated rat pancreatic islets to 1 mM 3-isobutyl-1-methyl-xanthine (IBMX) resulted in a 5.7-fold increase in the rate of insulin release. After a 30-min rest period under basal conditions, reexposure of the islets to 1 mM IBMX resulted in an enhanced rate of release when compared with either a timed contr...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.9.754
更新日期:1981-09-01 00:00:00
abstract::Single "subdiabetogenic" doses of streptozotocin (SZ), when given to young male CD-1 mice, produced a delayed onset of hyperglycemia dependent on the dose of SZ and on the age of the mice. The effect was markedly reduced or absent in older mice given the same dose of SZ per kg of body weight. Histologic examination of...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.9.718
更新日期:1981-09-01 00:00:00
abstract::Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In di...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.7.601
更新日期:1981-07-01 00:00:00
abstract::The increased sugar transport was examined in the isolated small intestine of streptozotocin-diabetic rats. In the small intestine of these animals, the rate of glucose absorption in vivo is slightly increased, but not that of galactose of 3-O-MG (3-O-Methylglucose); however, in the isolated small intestine, the mucos...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.7.568
更新日期:1981-07-01 00:00:00
abstract::Somatostatin-like immunoreactivity (SLI) concentrations were determined in human peripheral plasma using affinity chromatography followed by radioimmunoassay. In normal subjects, fasting SLI ranged from 2.9 to 22.0 pg/ml with a mean +/- SE value of 10.2 +/- 2.1 pg/ml. In totally pancreatectomized or gastrectomized pat...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.6.471
更新日期:1981-06-01 00:00:00
abstract::Platelet survival by 51chromium labeling was determined in six normal control subjects and in twelve patients with diabetes mellitus, before and after improved glucose control (mean HbA1c 10.5 +/- 2.2% and 7.1 +/- 1.8%, respectively). Mean platelet survival was 9.47 +/- 0.85 days for the normal subjects and 9.04 +/- 1...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.6.486
更新日期:1981-06-01 00:00:00
abstract::The stimulatory effect of the sodium ionophore, veratridine (10, 25 and 50 microM), on glucagon and insulin secretion was investigated using monolayer cultures of newborn rat pancreas. The results suggest that intracellular accumulation of sodium modulates hormone secretion from both alpha- and beta-cells. The action ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.5.446
更新日期:1981-05-01 00:00:00
abstract::The "M" variant of the encephalomyocarditis (EMC) virus causes a diabetes-like disease in some, but not all, strains of mice. The genetic basis for either resistance or susceptibility to the diabetogenic effect of the virus is not known. After infection with EMC, C57BL/6 mice seldom develop hyperglycemia and the insul...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.5.451
更新日期:1981-05-01 00:00:00
abstract::Plasma dopamine-beta-hydroxylase (pDBH) activity is markedly elevated in chronic experimental streptozotocin (STZ) diabetes in the rat. Several possible explanations, all potentially relevant to the pathophysiology of diabetes, could explain this observation. The objective of this paper was to further delineate the be...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.5.416
更新日期:1981-05-01 00:00:00
abstract::Recently, peptides with opioid-like activity have been demonstrated in peptic digests of dietary protein. The present study was designed to determine the effect of digested and undigested gluten on postprandial insulin and glucagon levels in conscious dogs. The intragastric instillation of digested gluten (25 g) elici...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.4.362
更新日期:1981-04-01 00:00:00
abstract::To determine the mechanism of hyperchloremic acidosis during recovery from diabetic ketoacidosis (DKA), serial measurements were made in eight patients of serum and urinary electrolytes and organic acids, and of urinary net acid. On admission, the average decrease in serum total CO2 was 17.5 mmol/L, corresponding to t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.4.310
更新日期:1981-04-01 00:00:00
abstract::A cohort of 372 insulin-dependent diabetic children, diagnosed between October 1949 and December 1960, were followed-up until December 1976 by the same team of physicians. At the time of diagnosis all patients were under 16 yr of age and were given standardized treatment which did not change from 1949 to 1976. The the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.3.175
更新日期:1981-03-01 00:00:00
abstract::To investigate how the D-cell recognizes the glucose stimulus, the hormone response to (1) glucose, (2) the trioses glyceraldehyde and dihydroxyacetone, (3) the metabolic blocker, mannoheptulose, and (4) the low- or nonmetabolized sugars galactose, fructose, or ribose were studied using the isolated dog pancreas. We f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.3.203
更新日期:1981-03-01 00:00:00
abstract::Endothelial cells in culture retain many of the functional properties of the endothelium in vivo. At high cell density, they become contact-inhibited. Endothelial cells, like vascular smooth muscle cells and fibroblasts, express binding sites for low density lipoprotein when depleted of sterol. In contact-inhibited en...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.2.s19
更新日期:1981-01-01 00:00:00
abstract::Based on studies of both man and rat, it is proposed that at least three distinct syndromes of hypertriglyceridemia occur as the result of abnormalities of carbohydrate metabolism. We believe that these syndromes are the predictable results of the changes in plasma insulin and/or free fatty acid (FFA) concentration th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.2.s66
更新日期:1981-01-01 00:00:00
abstract::A total of 32 pairs of obese fathers or mothers and their obese offsprings, aged 20 yr or younger, from 25 families with established hyperinsulinemic obesity aged 11-20 yr equally showed an insulin hyperresponse to glucose, the offspring 10 yr or younger revealed a rather normal insulin response, despite the presence ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.30.1.14
更新日期:1981-01-01 00:00:00
abstract::The influence of insulin on the intracellular free sodium and potassium ion concentrations ([Na+]i, [K+]i) and resting membrane potential of rat epididymal adipocytes was examined to determine its potential for mediating insulin's action on other cellular processes. Direct intracellular measurements of [Na+]i, [K+]i, ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.12.1040
更新日期:1980-12-01 00:00:00
abstract::Three forms of disulfide-linked insulin receptor complexes are labeled by covalent cross-linking to receptor-bound 125I-insulin in native adipocyte or liver membranes. These receptors of Mr 350,000 Mr 320,000, and Mr 290,000 are composed of alpha (Mr 125,000), beta(Mr 90,000), and beta 1(Mr 49,000) subunits in stoichi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.29.11.945
更新日期:1980-11-01 00:00:00
abstract::Rat pancreatic islets were incubated in vitro with L-[4,5-3H]leucine or with L-[2,3-3H]tryptophan in Krebs-Ringer bicarbonate buffer, containing 0, 5, or 20 mM glucose. Incorporation of labeled amino acids in islet cells was evaluated quantitatively by a validated radioautographic procedure. Incorporation of labeled l...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diacare.20.10.795
更新日期:1980-10-01 00:00:00